Nicotine

Nicotine Molecular FormulaThere are over 4,000 chemicals found in tobacco products and nicotine is one of them. Nicotiana tabacum, the type found in tobacco plants, is a naturally occurring colorless liquid chemical that directly acts on the brain. When burned, this chemical turns into brown and emits the odor of tobacco. As an alkaloid, nitrogen-containing chemical, nicotine may be synthetically produced.

Nicotine is easily absorbed through the mucosal lining of the mouth and nose, and the skin. It goes to the lungs through inhalation, which is the quickest way for nicotine to reach the brain, activating the “reward pathways” and thereby increasing the dopamine levels. It will only take 10 seconds of cigarette inhalation to reach peak levels of this drug, and quickly dissipating causing the user to continue to smoke throughout the day.

As an antiherbovire chemical, nicotine found in tobacco products is also used extensively as an insecticide.

Nicotine Transmission

Screening Cut-Off and Detection Time

It must be understood that tobacco is not the only source of nicotine. This chemical is naturally found in nightshade plants such as eggplants, tomatoes, potatoes, green peppers and coca plant leaves.

Nicotine is metabolized into cotinine once it enters the blood stream and slowly mixes with the blood. Nicotine is easily and quickly absorbed by the human body and taking quite a while to rid. Nicotine is detectable in the blood from 1-3 days after using. Using nicotine urine testing, it is detectable in the urine for up to 4 days. For heavy users nicotine may take 2-3 weeks before completely disappearing from the user’s system.

DEA Drug Class

Nicotine is addictive and can be toxic if taken in high doses. However, nicotine is not a controlled substance under the US Controlled Substance Act. As early as 1964, the US Surgeon General stated that smoking is linked to heart disease and lung cancer. Nevertheless it wasn’t until 1994 that the US Food and Drug Administration supported the issue that nicotine is addictive. In connection, the US Supreme Court ruled that the FDA has no right to regulate nicotine as a drug. In 2009, the Family Smoking Prevention and Tobacco Control Act gave the FDA the authority to control the manufacture and trade of tobacco.

What Type of Drug is Nicotine?

Nicotine, found in cigarettes, cigars, snuff, pipe tobacco, and chewing tobacco, is highly addictive. It is easily absorbed in the bloodstream when tobacco product is smoked, inhaled or chewed. Nicotine stimulates the adrenal glands to release epinephrine or adrenaline. Epinephrine increases respiration, blood pressure and heart rate as this hormone stimulates the central nervous system. Nicotine is similar to heroin and cocaine in the sense that all three chemicals increase the levels of the neurotransmitter dopamine, thus affecting the reward and pleasure brain pathways.

Forms and Routes of Administration

Nicotine is available in various products that contain tobacco. Such products contain different levels of nicotine but no amount is too little as to render this substance harmless.

  • Cigarette, Cigar, Cigarillos – These products are smoked and only a fraction of the nicotine content is directly inhaled as most of the smoke goes off at the side as one puffs. Toxicity is somewhat limited since the effects of inhaled nicotine happen within seconds. If ingested, nicotine toxicity may develop.
  • Chewing Tobacco – Also known as smokeless tobacco, nicotine in this product is absorbed through the mouth. Snuff is ground tobacco in sachets. The nicotine content of a 34g of smokeless tobacco is about 236 mg, whereas a pack of cigarette has 24 mg of nicotine.
  • Nicotine Gum–This nicotine product is used as an aid to stop smoking. The gum contains a minute amount of nicotine and raises the concentration of nicotine in the body at a slower pace than smoking a cigarette.
  • Nicotine Patch –Nicotine patches contain a sizeable amount of the substance in order to facilitate a continuous delivery for hours. Severe toxicity may happen if the patch is ingested.
  • E-cigarettes – Also called e-liquid or e-juice, e-cigarettes are a battery-powered device that vaporizes liquid nicotine. The concentrated nicotine is sometimes flavored, and packaged in 30 ml to 4 liters container.
  • Dissolvable Tobacco – This is a fairly new tobacco product that comes in sticks, strips, compressed tobacco and orbs. They look like candies, spit-free and smoke-free.
  • Hookah – This is a device made of pipe, a water bowl and hose used to smoke a combination of vegetable/fruit and tobacco (shisha). The tobacco is heated using charcoal or Bunsen burner to deliver about 100-200 times the volume of inhaled smoke from a cigarette.

Nicotine Forms of Administration

Tobacco Brand Names

There are hundreds of cigarette, cigar and other tobacco product brand names. Below are the top cigarettes, cigars, and smokeless tobaccos.

Cigarette Brands

  • Marlboro   
  • Newport    
  • Camel    
  • Pall Mall Box    
  • Pyramid

Cigar Brands

  • Swisher Little    
  • Swisher Sweets    
  • Black & Mild    
  • White Owl    
  • Dutch Masters    
  • Winchester

Smokeless Tobacco

  • Levi Garrett Plug
  • Day’s Work    
  • Red Man Plug
  • Grizzly    
  • Garrett    
  • Skoal    
  • Red Man

Nicotine Uses

In the past, low doses of nicotine were used to treat a variety of ailments from migraine to intestinal symptoms. High dose of nicotine is lethal that it has been used as insecticide. Studies indicate that there are many possible medical uses for the highly stigmatized nicotine. Pharmaceutical drugs with nicotine as their primary ingredients were developed for clinical trials in the treatment of depression, schizophrenia, depression, Alzheimer’s disease, ADHD, anxiety, Tourette syndrome, and other disorders.

It has been observed that people with  schizophrenia, adult ADHD and depressive –spectrum disorders tend to smoke heavily, prompting researchers that nicotine seems to soothe or diminish symptoms.

Nicotine also tends to improve the motor and cognitive functioning in people with Parkinson disease and Alzheimer disease. The theory is that nicotine increases the release of neurotransmitters diminished in those two diseases.

Studies are underway to determine the efficacy of nicotine as a pain reliever and postoperative analgesic.

Currently, nicotine is now being used as aid in smoking cessation called nicotine replacement therapy or NRT. The premise of this therapy is to lessen the craving for therapy and provide relief from withdrawal symptoms when a person is trying to quit or cut down on smoking.

Special Conditions

Smoking is linked to cancer, lung diseases, heart diseases, heart attack, vascular disease, emphysema, chronic bronchitis and aneurysm. The habit has also been linked to pneumonia, cataracts and leukemia.

When taken for medicinal purposes, the prescribing doctor must know if the patient has:

  • Stomach ulcer
  • Heart disease
  • Diabetes
  • Untreated high blood pressure
  • History of seizures
  • Food allergies

A person on low salt diet or using another smoking cessation medication are advised not to take nicotine gum or lozenges. People diagnosed with phenylketonuria cannot use nicotine gum or lozenges as they contain phenylalanine.

What Smoking Nicotine is Linked To

Street Names for Tobacco

  • Ciggies
  • Smokes
  • Stogs
  • Stogies
  • Stokes
  • Tabs
  • Snouts
  • Cigs
  • Chew
  • Dip
  • Snuff
  • Split tobacco

Nicotine Side Effects

Smokers know that tobacco use is harmful and most have the desire to quit or reduce using it. The truth is that out of the 35 million who wish to stop smoking each year, about 85% of them relapsed within a week.

The effects of smoking are serious as it can potentially harm all organs of the body.

Autoimmune System

Heart

  • Stroke
  • Aneurysm
  • Heart disease
  • Buildup of plaque in the arteries
  • Heart attack
  • Peripheral and arterial disease

Blood

  • Thickened blood vessels
  • Blood chemistry changes
  • Increased blood pressure

Vision

  • Optic nerve damage
  • Macular degeneration
  • Blindness

Bones

  • Bone loss
  • Osteoporosis

Lungs

  • Pneumonia
  • Emphysema
  • Chronic bronchitis
  • Asthma
  • Chronic obstructive pulmonary disease
  • Tuberculosis

Reproductive System

  • Stillbirth
  • Preterm birth
  • Orofacial clefts
  • Ectopic pregnancy
  • Erectile dysfunction

Short-Term Nicotine Side Effects

  • nausea or vomiting
  • mouth sores, blisters, or irritation
  • sore throat
  • belching
  • acid or sour stomach
  • dizziness
  • heartburn
  • mouth, tooth, jaw, or neck pain
  • problems with teeth
  • unusual tiredness or weakness
  • diarrhea
  • hiccups

Nicotine Addiction

Tobacco dependence or nicotine dependence simply means a person cannot stop using the nicotine products even if he knows it’s harmful to him and those around him.

The substance produces not only physical effects but mood-altering changes in the brain that is pleasurable. The pleasure affected by using tobacco may prod the person to dependence. Nicotine affects the brain by:

  • reducing depression
  • boosting mood
  • producing a sense of well-being
  • reducing irritability
  • enhancing short-term memory and concentration
  • reducing appetite

Symptoms of Use and Abuse

It is easy enough to know if a person smokes. His clothes, hair, hands and breath will usually smell like cigarettes. He might have a persistent cough that won’t go away. People who chew tobacco spits a lot, while those who use flavored e-cigarette would probably smell sweet and fruity.

Withdrawal symptoms appear when a tobacco-user stops its use. Symptoms may appear 30 minutes after the last hit.  Some of the more common symptoms are:

  • headaches
  • tingling in the hands and feet
  • nausea and intestinal cramping
  • coughing, sore throat
  • difficulty concentrating
  • irritability
  • intense cravings for nicotine
  • sweating
  • anxiety
  • insomnia
  • weight gain
  • depression

Stopping smoking can improve one’s health no matter how long the person has used tobacco products.

History of Tobacco

Nicotine was isolated from Nicoatiana tabacum in 1828, and was first synthesized by P. Crepieux and A. Pictet in 1904. However, the history of this drug dates back more than 2,000 years.

Native to the Americas, the tobacco plant has been used for medicinal and recreational purposes. Ancient carvings depicted Mayan priests enjoying a pipe of tobacco and have used the plant in sacred and healing rituals. Spanish conquistadors and travelers introduced tobacco for use in cigars and pipes.  

In 1560 French ambassador Jean Nicot de Villemain sent tobacco and seeds from Brazil to Paris believing that tobacco had medicinal value. Nicotiana tabacum which is the Latin name for the tobacco plant was derived from his name Nicot. He sent powdered tobacco to Queen Catherine de Medici for her to sniff the snuff to cure her migraines. The Queen of France said the snuff worked and called it the Herba Regina, or herb of the queen.

The new Spanish colonies in North America became the prime supplier of tobacco leaves in the 1600’s. The demand was so great that by the 1700’s, slave trade between North America and Africa prospered as more plantation workers were needed in North America. Thus, the proliferation of tobacco was virtually unstoppable as local economies prospered with the trade.

In 1763, nicotine was used as an insecticide. In 1828, German chemist Karl Ludwig Reinmann and Dr. Wilhelm Heinrich Posselt isolated nicotine from the tobacco plant. Both scientists deemed nicotine poisonous.

The ill effects of tobacco consumption were recognized that by 1890, several US states banned the sale of cigarettes to minors. Today, nicotine comes in a variety of products.