Opiates/Morphine

Opiates are naturally found in the opium poppy plant (Papaver somniferum). Morphine, thebaine and codeine are the psychoactive compounds found in the opium plant.

Opiate is under the broader term opioid, which includes the following: natural opiates such as codeine and morphine: semi-synthetic opiates such as oxycodone and hydrocodone; and synthetic opiates such as fentanyl and methadone.

Among opiates found in opium, morphine is the most abundant and the most potent pain reliever. This analgesic has been used to relieve pain from grave war injuries to the management of painful diseases. It is also illicitly used for recreational purposes by drug abusers. Opiate such as morphine has the potential to be highly addictive. It can cause incapacitating physical dependence that could severely affect the abuser physically and psychological dependence.

Natural vs. Semi-Synthetic vs. Synthetic Opiates

Screening Cut-Off and Detection Time

There are two required cut-off levels in drug testing to warrant positive detection. If the initial drug test proves negative then that means that drug detection is below the cut-off level. If the initial drug test result is positive, a confirmatory test is required for an accurate reading.

The initial cut-off levels for opiates which include morphine, heroin, codeine and opium is 2000ng/ml within a detection period of up to 2 days. Confirmatory cut-off level for morphine is also 300ng/ml.

DEA Drug Class

The Drug Enforcement Administration (DEA) is the agency in charge of drug-related production, trade, smuggling, use and abuse in the United States. The agency is the implementing body of the 1970 Controlled Substance Act (CSA). Based on the CSA there are five categories and schedules of substances, chemicals and drugs based on their medical use, safety and potential for abuse.

Opiates including morphine are Schedule II drug. Drugs under this category have potential for abuse. This group of drugs is currently accepted in treatment or for medical use with stringent restrictions in the United States. Abuse of opiates and morphine may lead to acute physical or psychological dependence.

Morphine Drug Type

Opiates in general, and morphine in particular are narcotic pain relievers. Opiates such as morphine are medically used to treat moderate to severe pain due to grave wounds, or sometimes after surgery for acute pain. This group of drugs not only relieves pain but also dulls the senses and induces deep sleep that could lead to coma if taken in excess.

There are two other types of opiates aside from natural opiates like morphine and codeine. The second type is synthetic opiates such as fentanyl and methadone. The third type is semi-synthetic opiates such as oxycodone and hydrocodone.

Narcotic Pain Relievers

Other Common Opiates

  • Buprenorphine
  • Fentanyl
  • Heroin
  • Hydrocodone
  • Dydromorphone
  • Dilaudid
  • Meperidine
  • Demerol
  • Methadone
  • Vicodine
  • Oxycontin
  • Lorcet

Forms and Routes of Administration

Opiates such as morphine may be taken orally, by injection, through transdermal patch or as a suppository. As this group of narcotic pain reliever comes in tablet form, it may be grounded into powder to be snorted.

  • Tablet – Some opiates including morphine come in tablet form of varying colors such as red, white, blue and black. Thus it is not uncommon to refer to morphine based on its color. Some crush the tablet and ingest it for stronger effect. Snorting powdered morphine results into an immediate “rush” as the drug goes straight to the user’s brain.
  • Solution – Some brands of morphine are in liquid form and given intravenously to patients for a more controlled and effective pain relief therapy. Abusers may crush morphine tablets and dissolve them in water or another liquid. The dissolved drug is then directly injected to the user’s vein. Injecting opiates without medical supervision is dangerous.
  • Transdermal patch – Some brands of morphine and opioids are medically administered by transdermal patch. The patch is attached to the arm or the buttocks of the patient. The purpose is to slowly release the drug for a period of 24-72 hours for pain relief therapy. Abusers have been known to cut the patch open and swallow or inject the gel in the patch.
  • Suppository – Some brands of morphine are available as suppository. The idea is to slowly release the drug for effective pain relief therapy.

Opiates Forms of Administration

Morphine Brand Names

  • Malfin
  • Maxidon
  • Micro-Morphine
  • Meslon
  • MCR, M-Dolor
  • Morapid
  • Morficontin
  • Moraxen
  • Morfina
  • Moretal
  • Morcap
  • Morph
  • Oblioser
  • Oramorph
  • Opsalvina
  • Painbreak
  • RA Morph
  • Relimal
  • Repriadol
  • Morphium
  • Moscontin
  • Morstel
  • Ordine
  • Morphiphar
  • Morfin
  • Morin
  • Opitard
  • MOS
  • Morstel
  • MS Contin
  • Embeda
  • Mundidol
  • Filnarine
  • Mortificontin
  • Dulcontin
  • Graten
  • GNO
  • Hospira
  • Duralgin
  • DepoDur
  • Dimorf
  • Infumorph
  • Kapabloc
  • Kadian
  • MS Direct
  • MS Long
  • MS Mono
  • Neocalmans
  • Noceptin
  • Nepenthe
  • Algedol
  • Amidiaz
  • Dolcontin
  • Rescudose
  • Anamorph
  • Relipain
  • Morphanton
  • Morphgesic
  • Morphin
  • Anafil
  • Astramorph
  • Actiskenan
  • Analmorph
  • Analfin
  • Avinza
  • CloruroMorfico Braun
  • Compensan
  • Depolan
  • Contalgin
  • Duralmor
  • Duramorph
  • Doltard
  • Epimorph
  • Doloral
  • Kapanol
  • Loceptin
  • Longphine
  • LA Morph
  • M-Eslon
  • M-Beta
  • M-Long
  • Novo-Morphine
  • M-Retard
  • M-Stada
  • PMS-Morphine
  • S-Morphine
  • Oglos
  • Ratio-Morphine
  • RMS, Roxanol
  • Morphex
  • Morphini
  • Vendal
  • Q-Med Morphine
  • Morphitec
  • Morphinum
  • Mogetic
  • OMS Concentrate
  • Statex
  • Substitol
  • Uni Mist
  • Onkomorphin
  • Sevre-Long
  • Slovalgin
  • SRM-Rhotard
  • Stellaphine
  • Stellorphinad
  • Slo-Morph
  • Stellorphine
  • Skenan
  • Sevredol
  • Zomorph5

Morphine Uses

Opiates such as morphine are one of the most powerful analgesics. For centuries, this group of drugs has been used to relieve pain and other symptoms, and to promote sleep.
Current major uses of morphine in clinical practice are:

  • Pain relief due to myocardial infarction or heart attack. The excruciating chest pain caused by a heart attack is quite severe, often radiating to the neck, head, back and inner side of the left arm. The pain causes undue apprehension, a sense of pending death, which adds more damage and stress to the heart. Taking morphine will ease the pain and take away the feeling of dread.
  • Relieves bone and joint pain linked to sickle cell disease.
  • Used before, during and after bone and large organs to ease pain.
  • Sometimes used for sedating (anesthesia) patients, and for epidural or spinal anesthesia.
  • Pain relief for severe injuries due to vehicular accidents, kidney stones passing or obstruction of the urinary tract, pulmonary edema, renal colic, rheumatoid arthritis, osteoarthritis, etc.
  • Pain relief for terminal patients, as part of palliative care given to patient with advanced diseases.
  • Suppressant for severe cough.
  • For relief of severe diarrhea.

Opiates Street Names

  • Mister blue
  • Dreamer
  • God’s drug
  • TNT
  • Tango and Cash
  • Dance Fever
  • Murder 8
  • Goodfella
  • M
  • Monkey
  • White Stuff
  • Auntie Em
  • Auntie
  • Black Tar
  • Morph
  • Drone
  • Black Stuff
  • Black mollies
  • Black pills
  • Miss Em
  • Miss Emma
  • White Lady
  • Salt and Sugar
  • Big O
  • Black Hash
  • Black Russian
  • Buddha
  • China White

Side Effects of Morphine

The use of opiates promotes pain relief and sedation. However, continuous use of this drug could lead to deterioration of one’s health and other complications. Sustained use of opiates could lead to abuse. Withdrawal symptoms could appear if the user stops taking the drug.
As narcotics alkaloids, opiates have a relaxing effect that makes users drowsy and sleepy. It is possible for a user to nod-off in the middle of an activity. Opiates such as morphine can cause depressed respiration and constipation. Physical side effects of morphine are:

  • Drug dependence
  • Produce physiological drug dependence
  • Watery eyes
  • Nausea
  • Diarrhea
  • Runny nose
  • Cramps
  • Loss of appetite
  • Dysphoria
  • Muscle aches
  • Anxiety
  • Restlessness
  • Irritation
  • Dilation of the Pupils
  • Tremors
  • Chills & sweating
  • Sensitivity to pain
  • Piloerection
  • Insomnia
  • Tachycardia

One of the psychological effects of morphine and other opiate is the short but intense feeling of euphoria. The user develops a sense of tranquility, comfort and pleasure from getting “high” that his main goal is to achieve that state. Psychological dependence may last years after the person stops taking opiates.

Other Effects of Opiate/Morphine Use and Abuse are:

  • Attaches to opioid receptors
  • Attaches to spinal cord
  • Attaches to the gastrointestinal tract
  • Central nervous system depressant
  • Physical dependence
  • Psychological dependence
  • Cognitive deficits
  • Long acting opioid receptor agonist
  • Potent central analgesic
  • Sedative
  • Antitussive action
  • Alters perception
  • Dissociative effect
  • Respiratory depression
  • Blockage of respiratory centers to CO2
  • Increased parietal glucose metabolism

Signs & Symptoms of Opiate Use

  • Nausea
  • Vomiting
  • Inability to cough or lack of cough reflex
  • Mood swings
  • Agitation
  • Irritability
  • Constipation
  • Water or fluid retention
  • Lack of physical appearance
  • Lack of hygiene
  • Track or needle marks
  • Pin point or very small pupils
  • Shallow or labored breathing
  • Extreme sleepiness
  • Mental cloudiness
  • Itchiness
  • Feeling sick but is quickly relieved when given opiate/morphine

Short-Term Side Effects of Morphine

  • Constipation
  • Decreased appetite
  • Labored breathing
  • Drowsiness
  • Dry mouth
  • Euphoria
  • Blurred vision
  • Feeling lightheaded
  • Hives
  • Interruption of menstrual cycle
  • Itching
  • Nausea
  • Red rash
  • Reduced sex drive
  • Respiratory depression
  • Slowed breathing
  • Sweating
  • Vomiting
  • Weakness
  • Weight loss
  • Irregular heartbeat
  • Tachycardia
  • Maybe life-threatening
  • Respiratory depression
  • Hallucinations
  • Confusion
  • Impaired judgment
  • Dizziness
  • Sedation
  • Mood swings
  • Dysphoria
  • Depressed reflexes
  • Chest pain light headed
  • Fainting
  • Headaches
  • Nausea
  • Facial flushing
  • Constipation
  • Muscle flaccidity
  • Dizziness
  • Thirst

Long-Term Side Effects of Morphine

  • Addiction
  • Bone damage
  • Blood damage
  • Bone pain
  • Brain damage
  • Comma
  • Constipation
  • Convulsions
  • Death
  • Depression
  • Emotional instability
  • Facial flushing
  • Itchy skin
  • Hot flashes
  • Kidney damage
  • Liver damage
  • Mood disturbances
  • Muscle flaccidity
  • Muscle pain
  • Pupil constriction
  • Renal failure
  • Stupor
  • Sweaty skin
  • Tolerance
  • Cardiovascular effect
  • Nausea
  • Sedative
  • Respiratory depression
  • Miotic

Special Conditions

Patients with breathing or asthma problems, paralytic ileus (bowel obstruction), or blockage in the stomach or intestines should not take morphine or any other opiate.

Opiates can slow or stop one’s breathing so this medicine must never be taken in large amount. This drug must never be taken by a pregnant woman as it may cause withdrawal symptoms in a newborn child.

Combining alcohol and morphine or any other opiate could have a dangerous side effect. It may even lead to death.

Morphine has a dangerous interaction with MAO inhibitors such as tranylcypromine, rasagiline, phenelzine, methylene blue injection, linezolid, isocarboxazid and more. Do not use any opiates or morphine until 14 days after taking MAO inhibitor.

  • Lung disease or any type of breathing problem
  • a history of brain tumor, head injury or seizures
  • a history of mental illness, drug abuse, or alcoholism
  • problems in urinating
  • problems with liver, kidney, gallbladder, thyroid, or pancreas

Opiate Addiction

Opiate or morphine dependence is the medical diagnosis given when a person develops an incapability to stop using morphine or any other opiates such as methadone, fentanyl, codeine or vicodin.

If a person displays at least three of the following symptoms mentioned below, the person is more likely to have opiate/morphine addiction.

  • Intense craving or desire for opiates/morphine
  • Incapable to control the level of use or use of opiates
  • Exhibits withdrawal symptoms when opiates are not used, or using the opiate of choice to prevent withdrawal symptoms
  • Develops tolerance to the drug so there is need to increase the dosage
  • Shows marked negligence on personal activities, work, or relations
  • Using the drug in spite of consequences pertaining to health, relationships and financial issues

Opiate Withdrawal Symptoms

  • Cramps
  • Joint pain
  • Chills and cold sweats
  • Restless leg syndrome
  • Flu-like symptoms
  • Yawning
  • Sneezing
  • Increased heart beat
  • Itching
  • Nausea
  • Muscle pain
  • Vomiting
  • Tremors
  • Diarrhea

Psychological Symptoms

  • Anxiety
  • Depression
  • Panic attacks
  • Insomnia
  • Intense cravings
  • Paranoia

History of Opiates

History of Opiates

India’s poppy fields were the British’s source of opium in the 18th century. At this time China and Britain trade was at its peak. China traded tea and silk to the British whereas the later brought opium sourced from India to China. As a consequence opium addiction became widespread in China prompting the Emperor to burn all opium brought in by British ship. This started the Opium Wars where Britain eventually won thus ensuring the continuation of the opium trade.

Many Asians migrated to the United States in the 18th and 19th century, bringing their opium with them. Thus, this drug became common in the United States and the rest of the world.

Scientists sought ways to preserve the medicinal properties of opium such as for cough suppression and pain relief, and at the same time modify the drug to make it less addictive.
After immersing opium in ammoniated hot water, Friedrich Wilhelm Serturner isolated a whitish-yellowish crystalline compound. He tested this substance in small doses on himself and others and found that the substance helped relieved pain and brought on a sense of euphoria. In large doses, the drug led to cough suppression, slower breathing, constipation, vomiting and nausea. He named his compound morphine, in honor of Morpheus, the Greek god of dreams.